Published-Structural determination of model phospholipid membranes by Raman spectroscopy

Sunghee Lee • January 20, 2022

The research group of Dr. Sunghee Lee at Iona College, New Rochelle, NY, has just published a peer-reviewed education article, titled “Structural Determination of Model Phospholipid Membranes by Raman Spectroscopy: Laboratory Experiment”, appearing in Biochemistry and Molecular Biology Education, a publication of Wiley (https://doi.org/10.1002/bmb.21603)

 

This article provides an experimental module designed to understand cell membranes through integrated concepts of chemical structure, molecular interactions, and membrane structural properties, using Raman spectroscopy of model cell membranes.

 

The main analytical tool used to investigate these systems is confocal Raman microspectrometer, an instrument acquired via a National Science Foundation (NSF)-Major Research Instrumentation (MRI) grant award (NSF-MRI-1427705). Since its introduction, the confocal Raman microspectrometer has been a central workforce for the enhancement of research and education at Iona College.

 

Many research papers in peer-reviewed journals have been published in recent years using confocal Raman spectrometer from the research group of Dr. Sunghee Lee, including "Ibuprofen and the Phosphatidylcholine Bilayer: Membrane Water Permeability in the Presence and Absence of Cholesterol" and "Molecular Organization in Mixed SOPC and SDPC Model Membranes: Water Permeability Studies of Polyunsaturated Lipid Bilayer".

 

However, the publication of this article has a special meaning, because, as an educational article, its techniques can be readily implemented to enhance students learning in Chemistry, Biochemistry, Molecular Biology, and related sciences such as Biophysics and Cell Biology, and has great potential for wide dissemination to the education community.

 

This project is a result of diligent work over the course of many years, and is coauthored by five undergraduates, Joseph Giancaspro (’20 Biochemistry), Patrick Scollan ('21 Biochemistry), Juan Rosario ('21 Biochemistry), Elizabeth Miller (’19 Biochemistry), Samuel Braziel (’18 Chemistry), under the guidance of Dr. Sunghee Lee. Samuel Braziel is the founding member of the Raman project, and who spent the most of his undergraduate research time to establish the protocols and initial parameterization, is now full-time employed in industry as an analytical scientist. Both Elizabeth Miller and Joseph Giancaspro, who dedicated themselves to developing optimum conditions of the method, are in Medical School, and Patrick Scollan (MS program in science education) and Juan Rosario (heading to Medical School) improved the application to the cell membrane models. This is truly an amazing harmonious team effort. Congratulations to the team!

Project Symphony at ACS Fall 2026

By Sunghee Lee • August 28, 2026
Project Symphony members proudly presented seven research posters at the ACS Fall Meeting in Chicago in the Biomaterials and Biointerfaces session of the Division of Colloid and Surface Chemistry. Presenting in this highly professional research setting—alongside graduate students and Ph.D.-level chemistry researchers—was a meaningful opportunity for our students to share their work, exchange ideas, and represent Project Symphony. This year’s group photograph is especially meaningful because it includes two Project Symphony alumni from the classes of 2015 and 2010, pictured at the far left and far right. Both are now accomplished scientists, and their return is a wonderful reminder of the lasting legacy of Project Symphony and the close-knit scientific community we have built over the past two decades. I am immensely proud of the hard work, dedication, and growth that led to these presentations. Congratulations to all of our presenters—keep up the excellent work!

Project Symphony Spotlight: Celebrating Colleen Clarke

By Sunghee Lee • May 18, 2026
We are proud to celebrate the continued success of former Project Symphony member Colleen Clarke, a Ph.D. candiate at Clemson University, who has recently received the first place in the poster session at the Women in the Global Battery Industry's Science Award. Colleen received this prestigious honor for her academic work on the impact of lignin on the transport of chemical properties of sulfonated ionomer composites for all-vanadium redox flow batteries. Colleen exemplifies the curiosity, dedication, and perseverance that Project Symphony strives to nurture in all of its participants. During her time with Project Symphony, Colleen demonstrated a strong commitment to scientific exploration and collaborative learning. Those early experiences helped shape her path toward advanced study and research, where she continues to excel and make meaningful contributions in her field. We are thrilled to see her accomplishments and look forward to following her continued success. Congratulations, Colleen—we are incredibly proud of you!

Celebrating Project Symphony at ISD 2026

By Sunghee Lee • April 24, 2026
On Thursday, April 16, 2026, our Project Symphony members presented their work at the 17th annual Iona Scholars Day, a campus-wide celebration of student scholarship and creative activity. This event showcases faculty-mentored projects across disciplines and highlights the depth of undergraduate research at Iona. This year, Project Symphony members contributed an impressive total of 15 research posters, representing months—and in many cases, years—of sustained effort, curiosity, and collaboration. Their work stood alongside projects from across the university, helping to put chemistry and biophysical research in the spotlight. As the PI of Project Symphony, I am deeply proud of each team member’s dedication, professionalism, and growth. Watching them explain complex ideas with clarity and confidence to faculty, peers, and visitors was truly inspiring. Their posters did more than present data—they told the story of how careful experimentation, persistence, and teamwork lead to new insights. Congratulations again to all of our presenters—you represented Project Symphony, with excellence.
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